Zesty Paws and Native Microbials will launch 2 products from an upcoming new line of supplements in the first half of 2026.
Zesty Paws and Native Microbials have partnered to launch a new line of canine gut health supplements that, according to Native Microbials, contain novel microbial species derived from the gut of healthy dogs. According to the company, the microbial strains were discovered through Native Microbials’ microbial genomics platform, which has fully mapped the canine microbiome.
Zesty Paws and Native Microbials plan to debut 2 products in the first half of 2026: a daily maintenance supplement and a higher-concentration product of microbial strains available in veterinary clinics. According to Native Microbials, the first product supports dogs with occasional diarrhea when administered at defined doses, whereas the second product will contain a clinical-strength quantity of novel microbial strains that may aid dogs experiencing more significant gastrointestinal (GI) issues.
Together, Zesty Paws and Native Microbials aim to transform how pet parents support their pets’ digestive health and will work to develop product formulations for dogs that Zesty Paws will commercialize and distribute in the United States, Native Microbials said.
"We're thrilled to partner with Zesty Paws to deliver first-of-its-kind microbial solutions that directly target GI health in dogs." Michael Seely, cofounder and CEO of Native Microbials, said in a news release.1 "We've only scratched the surface of what's possible with our microbial genomics platform, which can unlock entirely new classes of solutions for pets across a range of health needs. We look forward to expanding our partnership with Zesty Paws and bringing critical innovation to the companion animal health industry."
Treatment for Gi dysbiosis may include2:
Native Microbials says the new line of products has been preclinically studied to provide relief from GI dysbiosis (an imbalance in the gut microbiome) in dogs.1 In dogs, dysbiosis is characterized by decreased microbial diversity and a reduction in the bacterial species that produce short-chain fatty acids that help support the gut lining and the immune system.2 The condition is also accompanied by small intestinal bacterial overgrowth and changes caused by oral antimicrobial treatment.2 According to Native Microbials, its novel microbial strains support bile acid metabolism, generate beneficial short-chain fatty acids, and help rebalance microbial communities that affect digestion and immune health.
"At Zesty Paws, our mission has always been to elevate pet wellness through science-backed innovation and trusted quality," Akash Bedi, CEO of H&H Group North America and Europe, which owns the Zesty Paws brand, said in a news release.1 "This partnership with Native Microbials marks an exciting step forward—pioneering a new era of probiotics derived directly from healthy canine guts to better support balance and vitality in pets."
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