Zoetis shared the results from the first clinical trial comparing the NSAID meloxicam to Librela (bedinvetmab injection) for the management of canine osteoarthritis (OA) pain. The study, sponsored by Zoetis, was published in 

 and showed that the canine anti-nerve growth factor monoclonal antibody, showed equivalent pain relief to a NSAID. The data from the study was found to support guidelines that were previously published recommending both NSAIDs and Librela as a first line therapy for managing OA in canine patients.

"The results of this clinical trial provide veterinarians with the first data directly comparing the efficacy and safety of Librela to meloxicam. This new information is valuable for clinicians and pet owners when making treatment decisions for canine OA pain. My experience using Librela in the clinic for over 4 years aligns with the findings from this study," said John F. Innes, BVSc, PhD, DSAS(Orth), FRCVS, Royal College of Veterinary Surgeons. Specialist, Movement Referrals, in an organizational release.

The study was a randomized, open-label, and multicentered clinical comparator study following an ethical review by the Zoetis VMRD Ethical Assessment Committee. Dogs were eligible to participate through clinics that were randomly assigned 1 of 2 treatment groups based on the order in which they presented to the clinic. Each site was to attempt to enroll at least 2 complete blocks, which is 4 animals.

The patients in the study sample sizes were determined on the assumption that Librela would be superior to meloxicam when it came to efficacy, and the outcome measure was the Canine Orthopedic Index (COI). According to to the study, the sample size estimates using the COI required multiple assumptions first, published work indicated a standard deviation for COI in a population of dogs with OA to be “10” for the aggregate COI score and that treatment with the NSAID carprofen resulted in a mean decrease in COI score of 12.

The study enrolled 101 dogs with 52 randomized to Librela and 49 dogs randomized to meloxicam. The release noted that due to the small sample size and the short duration of the study, the statistical difference in adverse events (AE) numbers between each group could not be evaluated.

The study results indicated that Librela performed as well as meloxicam for managing pain associated with OA starting at day 14, the first time measured. Each product showed efficacy improving over the 56-day period. Within the study itself, it was noted that more dogs completed the study in the Librela group, 44, compared to the meloxicam group, 33.

 The results also showed that while there was a positive trend observed in mean reduction in the COI scoring, for the Librela group, there was a non-significant difference in efficacy each of the products. However, Librela was associated with fewer AEs compared to meloxicam.

Throughout the study, the following AEs were recorded and reported through the pharmacovigilance system

Seventeen dogs in the meloxicam group and 4 in the Librela group reported at least 1 AE

For the meloxicam group, 9 canines presented with gastrointestinal disorders, 3 musculoskeletal disorders, 3 neurological disorders, 1 skin and appendages disorder, and 1 behavioral disorder. 

For the Librela group, the AEs included 2 with musculoskeletal disorders, 1 with an interdigital cyst, and 1 systemic disorder, such as polydipsia

“Zoetis is committed to generating post-approval data on new innovations, like Librela. We previously shared study results showing that Librela improves quality of life in dogs. Zoetis supports peer-reviewed clinical research, and we are excited to see the results of those studies, such as this first comparative trial, being shared with veterinarians,” expressed Richard Goldstein, DVM, DECVIM-CA, DACVIM (SAIM), global chief medical officer and head of medical affairs at Zoetis.

Zoetis Announces Results from First Study Comparing Librela (bedinvetmab injection) to the NSAID Meloxicam. News release. Zoetis. March 24, 2025. Accessed March 26, 2025. 

https://news.zoetis.com/press-releases/press-release-details/2025/Zoetis-Announces-Results-from-First-Study-Comparing-Librela-bedinvetmab-injection-to-the-NSAID-Meloxicam-2025-xPPs4219G3/default.aspx

Innes JF, Lascelles DX, Bell D, et al. A randomized, parallel-group clinical trial comparing bedinvetmab to meloxicam for the management of canine osteoarthritis. 

. 2025;12. doi:https://doi.org/10.3389/fvets.2025.1502218

Articles

Results found Librela to have fewer adverse events and provided equal efficacy for managing osteoarthritis 

Librela and meloxicam comparison study results now available 

As pet ownership grows, access to care continues to be an issue. In response to the growing need for pet care, many veterinary clinics are opening new locations.

In addition to offering care to patients, some veterinary establishments are also working with their communities and taking new actions to support the broader animal care ecosystem, which includes pet owners.

Below are new veterinary facility openings, and more:

Elm City Vet, located near New Haven Green,  opened the doors to its new hospital. According to Elm City Vet, the practice has plans to offer services on the evenings and weekends to facilitate access to care. To mark its grand opening, the hospital will hold a ribbon-cutting ceremony March 27th. In addition to offering care to pets in New Haven and surrounding areas, the hospital is also partnering with and supporting local businesses, organizations—cohosting an inaugural pet festival in the area.

"We believe in being more than just a veterinary hospital—we want to be a valued part of the New Haven community," Casey Miller, Elm City Vet hospital manager, said in a news release.

 "By partnering with local businesses and events, we aim to strengthen the bond between pet owners and their city."

Negola’s Animal Care (Columbia, Maryland)

Negola’s Animal Care, a clinic in Columbia, Maryland, recently announced a new initiative to support government employees that are currently facing financial uncertainty. To support local families depending on government employment in the area, Negola’s is offering a new program that gives government workers a discount on all services and priority same-day appointments. Through this new program, government employees will have access to preventive care, diagnostic testing, dental procedures, and emergency treatment at the discounted rate.

“As federal cuts continue to impact job security and household finances throughout Maryland, Negola's Animal Care is stepping up to ensure that economic pressures don't force families to compromise on their pets' health needs,” wrote Negola’s in a news release.

Paws Up Veterinary—a clinic also located in Columbia, Maryland—will be joining Columbia’s Merriweather district this summer. According to news reports, Paws Up Veterinary recently signed a lease for a 3,920 sq ft space that will offer affordable care and will blend modern technology with a “hometown feel.”

“I see my patients and their owners as more than income and numbers. With the big increase in corporate ownership, much of that close interaction has been lost. I am honored and proud to co-found such a modern, progressive practice where a client will always be warmly welcomed with quality care and a personal touch,” Timothy Cujdik, DVM, cofounder of the clinic, said in a news release.

New veterinary hospital, Elm City Vet, (part of the Pieper Veterinary Family), opened March 17th in downtown New Haven. News release. Pieper Veterinary. March 18, 2025. Accessed March 26, 2025. 

https://prnmedia.prnewswire.com/news-releases/new-veterinary-hospital-elm-city-vet-part-of-the-pieper-veterinary-family-opened-march-17th-in-downtown-new-haven-302404948.html

Negola's Animal Care supports local government employees with same-day appointments and 15% discount amid a challenging government climate. News release. March 25, 2025. Accessed March 26, 2025. 

https://prnmedia.prnewswire.com/news-releases/negolas-animal-care-supports-local-government-employees-with-same-day-appointments-and-15-discount-amid-a-challenging-government-climate-302411153.html

Howard Huges signs lease with Paws Up Veterinary at Juniper in downtown Columbia’s Merriweather district. News release. Citybiz. March 20, 2025. Accessed March 26, 2025. https://www.citybiz.co/article/674416/howard-hughes-signs-lease-with-paws-up-veterinary-at-juniper-in-downtown-columbias-merriweather-district/

Yeager A. Veterinary clinic coming to Merriweather district. 

 March 21, 2025. Accessed March 26, 2025. https://www.bizjournals.com/baltimore/news/2025/03/21/visit-baltimore-names-interim-ceo-kireem-swinton.html

The latest updates relating to animal care establishments

Clinic center: Veterinary practice launches new initiative supporting government employees, and more 

The Senior Dog Veterinary Society is partnering with Loyal, a clinical-stage drug development company, to increase awareness about the importance of intentional care for older canines and to support veterinarians in providing care for these patients. Additionally, the organization recently announced a partnership with Elanco Animal Health, a manufacturer of therapies for managing chronic pain associated with canine osteoarthritis (OA), a common disease for aging dogs.

There are more than 26.5 million senior dogs in the US with this canine population growing at a rate of more than 10% annually over the past decade. The Senior Dog Veterinary Society was founded in 2023 by Lauren Adelman, DVM, DACVIM (SAIM), Monica Tarantino, DVM, MBA, and Lisa Lippman, DVM, to advance the growing need for care of senior and geriatric dogs as well as specialized knowledge and resources for practitioners. It offers continuing education (CE) courses, live events and branded resources to help improve patient outcomes.

Brennen McKenzie, MA, MSc, VMD, director of veterinary medicine at Loyal, said he knows firsthand how important it is to provide tailored care to senior dogs. He spent most of his career practicing veterinary medicine with small animals before pivoting to work with canine longevity drugs. “When the Senior Dog Veterinary Society first reached out to us, we were enthusiastic about working together towards our shared visions—to help all dogs live longer, healthier lives, including in their senior years. It’s been fun and rewarding to partner in promoting education for vets about the latest research and the newest clinical treatments our older canine friends need and deserve,” McKenzie said in a news release.

Loyal currently has 3 drugs in development that are designed to promote longer, healthier lifespans. Two of these drugs—LOY-001 and LOY-003—target large dogs, while the third, LOY-002, is intended for senior dogs. A daily pill, LOY-002 works to preserve metabolic health, which helps mitigate age-associated diseases, according to Loyal. 

 with a reasonable expectation of effectiveness designation in February 2025, and is forecasted for market availability in the next year.

Loyal is currently running the STAY clinical study to further examine LOY-002, and to provide effectiveness and field safety data for its’ FDA application for drug approval. In a 

interview, Ellen Ratcliff, DVM, vice president of clinical and veterinary medicine at Loyal, said the study has been running in approximately 70 US veterinary clinics. “It doesn’t do anybody any good if their dog lives longer, but they live longer in that period at the end of the life where they don’t feel well, and they’re sick, having all kinds of degenerative and aging diseases. So, the STAY study is also measuring quality of life according to the owner and the owner assessment of the dog’s quality of life,” Ratcliff said.

Adelman said partnering with Loyal is a major step for her organization’s mission to improve the care, comfort and quality of life for aging canines, in a news release. CE, informational articles and social media are included in the collaborative initiative, which also aims to advance solutions that help all dogs live a longer, healthier lifespan.

 “By combining our expertise in senior dog health, we can equip veterinarians and pet owners with innovative solutions and crucial education to help dogs live longer, happier lives,” she said.

In January 2025, the Senior Dog Veterinary Society entered into a strategic alliance with Elanco Animal Health that includes a focus on research and innovation. In a news release, Stephanie H. Loter, DVM, medical strategic lead, pain management for Elanco, said the company was “thrilled” with the partnership.

 “As pets live longer lives, their health needs evolve, and this partnership will help ensure that senior dogs receive the care and attention they deserve to thrive in their golden years,” Loter said.

Tarantino said the alliance with Elanco allows The Senior Dog Veterinary Society to expand its’ reach and impact. “Together, we can provide invaluable support to dog owners and the veterinary community,” she said in a news release.

The Senior Dog Veterinary Society’s programming also provides opportunities for veterinary professionals to earn credentials through 2 RACE-approved courses. The organization’s Level 1 certification is a 7-hour course that provides fundamentals of senior and geriatric canine care for veterinarians, specialists, technicians, assistants, and receptionists. Its’ 7 modules include introductions to senior dog care programs, communication with senior dog owners, and canine geroscience. The Level 2 certification course is 7.5 hours and is designed more for veterinarians, specialists and technicians. It offers focus on specialized areas in 7 modules that include end of life care, senior dog dentistry and common eye abnormalities in the older canine population.

Senior Dog Veterinary Society and Loyal Partner to increase awareness of senior dog care. News release. Loyal and Senior Dog Veterinary Society. March 26, 2025.

Senior Dog Veterinary Society announces strategic alliance with Elanco. News release. Senior Dog Veterinary Society. January 23, 2025. Accessed March 26, 2025. 

https://www.seniordogvets.com/_files/ugd/01d0db_1cec041010044635968870e15b617a32.pdf

Crossley KC. Second drug for canine healthy lifespan extension receives FDA support. 

. February 26, 2025. Accessed March 26, 2025. 

https://www.dvm360.com/view/second-drug-for-canine-healthy-lifespan-extension-receives-fda-support

Senior dog CE topics. Senior Dog Veterinary Society. Accessed March 25, 2025. 

https://www.seniordogvets.com/certification

Longevity drug developer Loyal and pain therapy manufacturer Elanco Animal Health are working with the organization to promote the need for aging canine care and enhance veterinary resources.

The Senior Dog Veterinary Society forges partnerships to improve patient care

Jb Minter, DVM, MS, DACZM, discusses potential complications that can arise when amphibians are under anesthesia

Minimizing anesthetic risks in amphibian patients

Navigating Amphibian Anesthesia and Analgesia

, presented at the 2025 Fetch dvm360 Conference in Charlotte, North Carolina, Jb Minter, DVM, MS, DACZM, director of animal health and chief veterinarian at the North Carolina Zoo in Asheboro, North Carolina, talks about anesthetic risks in amphibian patients. Minter explains that these risks are similar to the ones mammalian patients face and offers advice for minimizing complications in these animals.

Below is the interview transcript, lightly edited for clarity:

When I think about anesthetic complications with my amphibian patients, they're very similar to the ones that I would think about for my mammalian patients.

So hyperthermia is one. So since like I said, I mentioned that amphibians are ectothermic...which means they [have] an inability to maintain their own body temperature. Maintaining that appropriate body temperature during anesthesia is going to be critical. So if the temperatures drop too low, that slows down their metabolic rate quite a bit and that basically includes their drug metabolism, which can potentially lead to prolonged anesthesia recovery or even death, if you've gotten them too chilly.

So ways of minimizing that...just provide them some type of warming support. Cardiovascular compromise, again, if they get a little chilly, they have a lower heart rate anyways and lower blood pressure. So...again, going back to that temperature regulation, it can become problematic for amphibians with these limited cardiovascular reserves, so you want to make sure that you use lower doses of drugs and then maintain that optimal temperature range.

And then another one I always like to think about is, again, they rely heavily on their skin for gas exchange and certain anesthetic agents can depress that respiratory function, which can lead to hypoxia. So just closely monitor their oxygen output and [make] sure that they're breathing throughout the process.

Videos

The University of Florida College of Veterinary Medicine (CVM) in Gainesville has adopted a scribe platform powered by artificial intelligence (AI) for use across its’ veterinary facilities and in classroom settings. The university chose ScribbleVet, which is used by thousands of veterinarians, because the platform offers high-accuracy, ease-of-use, and time-saving efficiency, according to a news release.

"The University of Florida is the first educational institution to adopt ScribbleVet system-wide, for both veterinary facilities and student use," Rohan Relan, founder and CEO of ScribbleVet, said in a news release.

The digital scribe utilizes AI to record appointments and complete veterinary SOAP (Subjective, Objective, Assessment and Plan) notes during patient exams. Veterinarians may have the opportunity to finish their medical notes and complete patient record-keeping within minutes, rather than hours, each day while using ScribbleVet.

"We chose ScribbleVet for its high accuracy and time-saving workflows, which allow clinicians to reclaim hours for patient care while seamlessly incorporating AI into student training,” Andrea Miller, associate director of operations at the CVM, said in a news release. "This collaboration reflects our leadership in veterinary AI innovation, equipping future professionals with the tools to streamline workflows, advance diagnostics, and elevate standards of care.”

The use of AI in research and education is not new for UFCVM. In 2023, university officials shared that investigators in the veterinary college had access to supercomputing and machine learning. With these tools, they had the ability to apply AI techniques to uterine microbiota in dairy cows to prevent metritis and had adapted microbiota for canine dermatitis treatment. Additionally, one faculty member’s role was to utilize AI technology and machine learning to develop diagnostic and clinical applications for comparative oncology and translational medicine.

The new initiative with ScribbleVet creates new opportunities. "We're excited to assist the university in teaching practices and students about ways they can leverage artificial intelligence to free up their time, minimizing administrative tasks and maximizing patient attention," Relan said,

ScribbleVet also recently announced an integration with LifeLearn.

 The collaboration allows veterinary practices using ScribbleVet’s service to immediately access the differential diagnostics in LifeLearn’s Sofie, a decision support tool that provides answers to pet health questions, and provide deep research within its’ SOAP notes.

University of Florida adopts ScribbleVet AI scribe tools for veterinary facilities, students. News release. ScribbleVet. March 25, 2025. Accessed March 25, 2025. 

https://www.prnewswire.com/news-releases/university-of-florida-adopts-scribblevet-ai-scribe-tools-for-veterinary-facilities-students-302410867.html?tc=eml_cleartime

College rises to No. 7 in the latest U.S. News & World Report rankings. News release. University of Florida College of Veterinary Medicine. April 25, 2023. Accessed March 25, 2025. 

https://www.vetmed.ufl.edu/2023/04/25/college-rises-to-no-7-in-latest-u-s-news-world-report-rankings/

Two companies are integrating AI-based tools for enhanced SOAP notes. 

. March 3, 2025. Accessed March 25, 2025. 

https://www.dvm360.com/view/two-companies-are-integrating-ai-based-tools-for-enhanced-soap-notes

ScribbleVet announced the University of Florida as the first first educational institution to adopt the digital solution system-wide for veterinary uses.

Veterinary college incorporates AI scribe into facilities and classrooms

Base Molecular Resonance Technologies (BMRT), a startup specializing in advanced detection technology, has developed a novel tool that can noninvasively detect poultry infected with avian influenza. The technology can also be used to detect up to 200 types of cancers and other diseases, drugs, gunpowder, and other substances, according to a recent announcement by BMRT.

The technology—Base Molecular Resonance (BMR)—can detect particle interactions at subatomic levels using resonant frequencies. The innovation uses scanning technology that can detect any compound or biological substance, including any element on the periodic table, as well as various cancers and avian influenza based on molecular structure.

“The non-invasive, harmless, and instant scan has broad implications in cancer diagnostics, public safety, law enforcement, security, and military services,” wrote BMRT in a news release.

The tool’s new application for detecting animals infected with avian influenza can help prevent the mass slaughter of poultry amid avian influenza outbreaks, as BMR has the ability to differentiate infected birds from healthy ones instantaneously, according to the company.

 "Right now, millions of chickens are being slaughtered out of fear rather than necessity. Our technology eliminates that uncertainty. With a simple scan, we can pinpoint infected animals with 100% accuracy, allowing farmers and regulators to respond with surgical precision instead of widespread devastation,” Robert “Bo” Short, co-founder and CEO of BMRT, said in a news release.

 “This is a major step forward for global food security, animal welfare, and the agricultural economy."

More than 166 million birds, including chickens and turkeys, have been slaughtered in the United States since the start of the avian influenza outbreak, with many of these birds being healthy.

 According to BMRT, testing data suggest that only 5% to 10% of these animals would have likely tested positive for avian influenza.

 More than 20 million egg-laying chickens were culled in the only the last quarter, costing poultry farmers hundreds of millions of dollars, affecting food production and driving egg prices, and putting a strain on supply chains.

Last year, the company announced that a study from York St John University’s Center for Applied Innovation in York, England, confirmed BMR had 100% accuracy in detecting cancerous tissues, nuclear elements, gunpowder, and more, in blind and double-blind tests.

 The research was led by Phillippe B. Wilson, PhD, PGCHE, president-elect of the Comparative Medicine Council at the Royal Society of Medicine and associate pro vice-chancellor for Innovation and Knowledge Exchange and professor of One Health at York St John University.

“The same precision and reliability now apply to disease detection in the agricultural industry, making it possible to safeguard global food supplies with unprecedented efficiency,” wrote BMRT in its most recent announcement.

A potential use for detecting other diseases in animals

According to BMRT, their BMR technology can also be adapted to detect diseases in cattle, swine, and other livestock, offering a valuable tool in preventing major outbreaks, including bovine spongiform encephalopathy, African swine fever, and foot-and-mouth disease.

"Bird flu is just the beginning. We can detect disease in livestock at the molecular level before symptoms even appear, allowing for rapid intervention that safeguards the food supply and protects farmers from catastrophic losses,” said Lee Duke, co-founder and president of BMRT, in a company release.

“This is the future of disease detection."

Base Molecular Resonance Technologies introduces game-changing solution to stop mass livestock culling amid bird flu crisis. News release. Base Molecular Resonance Technologies, LLC. March 13, 2025. Accessed March 25, 2025. https://prnmedia.prnewswire.com/news-releases/base-molecular-resonance-technologies-introduces-game-changing-solution-to-stop-mass-livestock-culling-amid-bird-flu-crisis-302401169.html

About us. Base Molecular Resonance Technologies, LLC. Accessed March 25, 2025. 

Landmark study confirms unprecedented 100% accuracy in quantum physics technology breakthrough for public safety, law enforcement, military applications, and cancer detection. News release. Base Molecular Resonance Technologies, LLC. July 11, 2024. Accessed March 25, 2025. 

https://www.prnewswire.com/news-releases/landmark-study-confirms-unprecedented-100-accuracy-in-quantum-physics-technology-breakthrough-for-public-safety-law-enforcement-military-applications-and-cancer-detection-302193686.html

The innovation also has the potential to detect other diseases in livestock, in addition to detecting up to 200 types of cancers